About
Physical Characteristics
Caps:
Small to medium size, smooth texture, often white or very pale due to albinism.
Gills:
Attachment adnate to adnexed, initially pale, becoming purple-black with maturity due to spore color.
Cognitive Effects
Enhanced Creativity
Users often experience a surge in creative thought and associative thinking.
Psychoactive Effects
Euphoria
A pronounced sense of happiness and well-being.
Helps With
Depression
Some studies suggest psilocybin can reduce symptoms of depression.
PTSD
Potential to help with post-traumatic stress disorder by facilitating emotional release.
Potential Side Effects
Nausea
Can occur shortly after ingestion, typically transient.
Anxiety
May cause anxiety or paranoia, particularly at higher doses.
Medicinal Chemistry
Look Alike Species
Specie: | Differences: | |
---|---|---|
![]() | Psilocybe azurescens Edibility:Psychoactive | Darker cap color and prefers to grow in colder climates. |
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Specie:
Psilocybe azurescens
Edibility:
Psychoactive
Differences:Darker cap color and prefers to grow in colder climates.
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References
Phylogenomics of the psychoactive mushroom genus Psilocybe and evolution of the psilocybin biosynthetic gene cluster
Therapeutic use of psilocybin from “magic mushrooms” is revolutionizing mental health treatment for many conditions, including depression, PTSD, and end-of-life care. However, knowledge of Psilocybe diversity and its evolutionary history is substantially incomplete. Our study presents the most extensive phylogenomic dataset across Psilocybe to date, with 23 samples derived from type specimens. Using ~3,000 single-copy gene families, we recovered a robust and well-supported phylogeny. Mapping psilocybin biosynthetic gene orthologs on the phylogeny revealed two types of gene cluster order corresponding to a deep split in the genus. Molecular dating suggests psilocybin biosynthesis arose in Psilocybe ~67 mya, concurrent with the K-Pg mass extinction event. A significant advancement in the understanding of Psilocybe evolution and psilocybin biosynthesis is presented.
2024