Psilocybe Cubensis
"Cubes, B+"
![[object Object]](https://d16q8n2b2c01ef.cloudfront.net/media/PE1_new-800x450.webp)
Scientific Classification
About
Penis Envy #6 (often abbreviated as PE6) is a hybrid variant of Psilocybe cubensis, created by crossing the Penis Envy strain with a traditional cubensis strain. The result is a mushroom that combines high potency with more consistent fruiting and larger yields, making it one of the most popular strains among cultivators and psychonauts seeking a powerful yet manageable experience.
History
The original Penis Envy strain is famous for its unique morphology and strong effects but is notoriously difficult to cultivate. To improve its practicality, PE6 was developed (allegedly by mycologist John W. Allen and collaborators) by crossing it with a standard P. cubensis. This variant preserves much of the visual intensity and mental depth of classic Penis Envy while being easier to grow, faster to colonize, and producing more spores—an important trait for propagation.
Today, PE6 is widely respected for offering a balanced experience: spiritual and introspective, but less overwhelming than its parent strain.
Overview
PE6 mushrooms display thick, bulbous stems and moderately large caps, often more open and circular than the original Penis Envy. The coloration ranges from golden to caramel brown. They bruise blue intensely, indicating high levels of psilocybin and psilocin. Unlike the original PE, PE6 can drop viable spores, making it a preferred choice for cultivators.
Effects are described as deeply visual, introspective, and emotionally significant, often accompanied by body tingles and a sense of unity or revelation. It's a popular strain for both ceremonial use and recreational exploration, providing a potent but more forgiving trip.
Physical Characteristics
Caps:
Conical, falic-shaped
Gills:
Narrow to slightly enlarged in the center, pallid and grayish
Cognitive Effects
Creativity
Many individuals report heightened creativity and a sense of increased ideational fluency while under the influence of psilocybin. This may include enhanced problem-solving abilities, novel insights, and out-of-the-box thinking.
Psychoactive Effects
Hallucinogenic
Induces hallucinations - seeing, hearing, or feeling sensations that seem real but are not.
Euphoric
Creates intense feelings of happiness or excitement
Perceptual
Changes in time perception, spatial perception, and perception of one's own body
Pharmacology
Helps With
Depression
Provides relief from feelings of severe despondency and dejection
Anxiety
Helps to alleviate feelings of worry, fear, and unease
Addiction
Helps to overcome dependence on a particular substance, thing, or activity
PTSD
Helps to alleviate symptoms of post-traumatic stress disorder
OCD
Helps to alleviate symptoms of obsessive-compulsive disorder
ADD ADHD
Helps to alleviate symptoms of attention deficit disorder and attention deficit hyperactivity disorder
Pain
Microdosing psilocybin has been shown to help with certain types of pain
Migraines
Research shows that psilocybin, the active compound in magic mushrooms, has potential therapeutic benefits for migraines. A small-scale study conducted by Yale School of Medicine found that a single dose of psilocybin reduced the likelihood of having a migraine attack in two weeks.
Possible Side Effects
Nausea
Can cause discomfort or distress in the stomach accompanied by an urge to vomit
Paranoid
Induces an extreme, irrational distrust of others
Chemical Constituents
Medicinal Chemistry
Similar Species
![[object Object]](https://d16q8n2b2c01ef.cloudfront.net/media/GalerinaMarginata_new-400x400.webp)
Species: Galerina marginata
Edibility: Poisonous
Key Differences: Galerina marginata has a more brownish cap and does not bruise blue like Psilocybe cubensis.
![[object Object]](https://d16q8n2b2c01ef.cloudfront.net/media/GalerinaMarginata_new-400x400.webp)
Species: Galerina marginata
Edibility: Poisonous
Mushroom Ratings
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References
- Kryskow, P., Stamets , P., La Torre, J., Sattler, K., Tsang, V. W., & Williams, M. (2024). The mushroom was more alive and vibrant”: Patient reports of synthetic versus organic forms of psilocybin. .
- Bradshaw, A. ., Ramírez-Cruz, V., & Dentinger , B. (2024). Phylogenomics of the psychoactive mushroom genus Psilocybe and evolution of the psilocybin biosynthetic gene cluster. .
- Sekssaoui, M. (2024). Antidepressant-like effects of psychedelics in a chronic despair mouse model: is the 5-HT2A receptor the unique player?. .
- Ley, L. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants. .
- Bae, S. (2023). Cardiac Arrest Associated With Psilocybin Use and Hereditary Hemochromatosis. .
- Schindler, E. (2022 ). Exploratory investigation of a patient-informed low-dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double-blind, placebo-controlled trial. .
- Barrett, F. (2022). Human Cortical Serotonin 2A Receptor Occupancy by Psilocybin Measured Using [11C]MDL 100,907 Dynamic PET and a Resting-State fMRI-Based Brain Parcellation. .
- Desai, S. (2022). Hopelessness, Suicidality, and Co-Occurring Substance Use among Adolescent Hallucinogen Users—A National Survey Study. .
- McKernan, K., Kane, L., Helbert, Y., Zhang, L., Houde, N., & McLaughlin, S. (2021). A whole genome atlas of 81 Psilocybe genomes as a resource for psilocybin production.. .
- Rucker, J. (2021). Psilocybin: From Serendipity to Credibility?. .