About
Physical Characteristics
Caps:
Convex to broadly convex to plane at maturity, smooth, viscous when moist, golden brown.
Gills:
Adnate to adnexed, narrow, close, gray to nearly black in maturity.
Cognitive Effects
Enhanced Creativity
Users report an increase in creative thought processes.
Psychoactive Effects
Euphoria
Feelings of happiness and well-being are commonly experienced.
Helps With
Depression
Studies suggest potential benefits in treating depression.
Anxiety
Can reduce symptoms of anxiety in some users.
Potential Side Effects
Nausea
Can occur shortly after ingestion, usually transient.
Paranoia
Some users may experience heightened paranoia.
Medicinal Chemistry
Look Alike Species
Specie: | Differences: | |
|---|---|---|
 | Psilocybe cyanescens Edibility:Psychoactive | P. cyanescens has a more pronounced wavy cap and typically grows in wood chips or woody debris, whereas P. cubensis grows in dung or heavily manured soil. |
Specie:
Psilocybe cyanescens
Edibility:
Psychoactive
Differences:P. cyanescens has a more pronounced wavy cap and typically grows in wood chips or woody debris, whereas P. cubensis grows in dung or heavily manured soil.
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References
A whole genome atlas of 81 Psilocybe genomes as a resource for psilocybin production.
The Psilocybe genus is well known for the synthesis of valuable psychoactive compounds such as Psilocybin, Psilocin, Baeocystin and Aeruginascin. The ubiquity of Psilocybin synthesis in Psilocybe has been attributed to a horizontal gene transfer mechanism of a ~20Kb gene cluster. A recently published highly contiguous reference genome derived from long read single molecule sequencing has underscored interesting variation in this Psilocybin synthesis gene cluster. This reference genome has also enabled the shotgun sequencing of spores from many Psilocybe strains to better catalog the genomic diversity in the Psilocybin synthesis pathway. Here we present the de novo assembly of 81 Psilocybe genomes compared to the P.envy reference genome. Surprisingly, the genomes of Psilocybe galindoi, Psilocybe tampanensis and Psilocybe azurescens lack sequence coverage over the previously described Psilocybin synthesis pathway but do demonstrate amino acid sequence homology to a less contiguous gene cluster and may illuminate the previously proposed evolution of psilocybin synthesis.
2021