Cordyceps Militaris And Its Cordycepin Rich Extracts: A Review Of Health Benefits
By Josh Shearer on 07/01/2023
In the intricate world of health supplements, one natural contender has steadily been gaining attention: Cordyceps Militaris. This fungus, recognized for its therapeutic properties... To edit this post, navigate to the admin dashboard.
The Mighty Militaris
Cordyceps Militaris is an edible fungus species, a less-known relative of the common button or Portobello mushrooms. It grows predominantly in Asia, Europe, and North America, known to parasitize insects and other fungi in nature. While its growth habits may seem bizarre, it's the compounds within Cordyceps Militaris that make it so sought-after.One compound that stands out in the Cordyceps Militaris treasure chest of beneficial ingredients is cordycepin. It's not exclusive to Cordyceps Militaris but is found in significantly higher quantities here than in other Cordyceps species or fungi.Cordycepin: The Star of the Show
Cordycepin, chemically known as 3’-deoxyadenosine, is a derivative of the nucleoside adenosine. Its resemblance to adenosine allows it to interact with many biological pathways, accounting for its broad spectrum of potential health benefits.Health Benefits or Cordycepin
Here, we focus on the various health benefits associated with cordycepin-rich Cordyceps Militaris extracts. It's crucial to understand that while research into these benefits is promising, it's still ongoing. The potential benefits include:Enhanced Immunity
Cordycepin, a compound found in Cordyceps Militaris, may play a vital role in strengthening the body's immune system. Scientific studies suggest that this medicinal mushroom can positively impact different immune cells, thereby potentially augmenting the body's ability to ward off infections.Anti-Inflammatory and Antioxidant Properties
Cordycepin possesses strong anti-inflammatory and antioxidant properties. Its potential to suppress inflammation and combat oxidative stress may be beneficial in managing chronic conditions like heart disease and arthritis.Potential Anti-Cancer Effects
While the research is in preliminary stages, some studies suggest cordycepin may exhibit anti-cancer properties. Its ability to inhibit cell growth and induce apoptosis (programmed cell death) in certain cancer cells is being closely studied.Energy and Athletic Performance
Historically, Cordyceps Militaris has held a significant place in traditional practices for its potential to augment energy and enhance athletic abilities. Contemporary research underscores these traditional beliefs, indicating that cordycepin could play a role in optimizing exercise performance by escalating ATP production – the primary energy source for muscle contractions. In addition to these benefits, cordycepin may also have positive implications for male reproductive health. Preliminary studies suggest that Cordyceps Militaris, with its rich cordycepin content, could potentially enhance male reproductive functions. This multifaceted fungus appears to support various aspects of male performance, from fostering physical stamina to possibly aiding in improving aspects of male fertility. Though these findings are promising, they are still in the early stages, and more research is needed to fully understand cordycepin's role in male performance and reproduction. As with any new supplement, always consult with a healthcare professional before incorporating Cordyceps Militaris or cordycepin into your routine, particularly if you have pre-existing health conditions or are taking other medications.Neuroprotective Effects
Early research suggests cordycepin might help protect neurons against damage, potentially delaying the onset of neurodegenerative diseases such as Alzheimer's and Parkinson's. In conclusion, the Cordyceps Militaris fungus and its cordycepin-rich extracts hold exciting potential in health and wellness. As research continues to explore and validate these potential benefits, Cordyceps Militaris may soon emerge as a significant player in natural supplements. Remember, while the potential health benefits are promising, Cordyceps Militaris should be taken as part of a balanced diet and not as a replacement for traditional treatment. Always consult with a healthcare professional before adding new supplements to your regimen. With that, we hope this article has served as a valuable introduction to the intriguing world of Cordyceps Militaris and its cordycepin-rich extracts, setting you on a path of exploration into the world of natural health supplements.Related posts
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References
Protective effect of Cordyceps sinensis against diabetic kidney disease through promoting proliferation and inhibiting apoptosis of renal proximal tubular cells
Apoptotic effect of cordycepin on A549 human lung cancer cell line
Selective extraction of cordycepin from Cordyceps militaris – optimisation, kinetics and equilibrium studies
Structure and hypoglycemic activity of a novel exopolysaccharide of Cordyceps militaris
Biomass and Cordycepin Production by the Medicinal Mushroom Cordyceps militaris—A Review of Various Aspects and Recent Trends towards the Exploitation of a Valuable Fungus
Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21
Cordycepin: a bioactive metabolite with therapeutic potential
Impact of different fermentation characteristics on the production of mycelial biomass, extra-cellular polysaccharides, intra-cellular polysaccharides, and on the antioxidant activities of Cordyceps militaris (L.) Fr. (strains AG-1, PSJ-1)
Cordyceps militaris Grown on Germinated Soybean Induces G2/M Cell Cycle Arrest through Downregulation of Cyclin B1 and Cdc25c in Human Colon Cancer HT-29 Cells
Immunological Investigation of Polysaccharides from Fermented Cordyceps Cs-4 in Healthy and Immunosuppressed Mice
This study demonstrates the nephroprotective effects of Cordyceps sinensis, which functions via promoting proliferation and inhibiting apoptosis of renal proximal tubular cells, likely targeting VEGFA and PTEN. Furthermore, the AKT and ERK signaling pathway may be critical.
2023
Cordycepin, an active ingredient in the insect fungus Cordyceps militaris, is in a category of compounds that exhibit significant therapeutic activity. The aim of the present study was to investigate the effect of cordycepin on cell proliferation, apoptosis, and cell cycle in A549 human lung cancer cells. MTT assay was used to evaluate the cytotoxic effect of cordycepin on A549 cell growth. Apoptotic effect was observed using cell morphology, DAPI staining, and DNA fragmentation studies.
2022
Cordycepin was separated successfully from Cordyceps militaris using extraction with a mixture of ethanol and water. Optimum temperature, composition of ethanol in water, solvent/solid ratio and pH of solvent were determined by a central composite design (CCD) with respect to extraction yield. The highest yield for cordycepin (96%) was predicted by the regression model and validated by comparison with the experimental results, showing good agreement.
2022
A novel neutral exopolysaccharide (EPS-III) was isolated from culture broth of Cordyceps militaris (C. militaris). The EPS-III was a homogeneous polysaccharide with Mw of 1.56 x 10(3) kDa. The yield of EPS-III from culture broth was 123.2 +/- 3.1 mg/L and the sugar content was 93.32 +/- 0.87%. The backbone of EPS-III was mainly consisted of –>4)-alpha-D-Galp-(1–>, while –>3, 6)-alpha-D-Manp-(1–>, –>4)-alpha-D-Manp-(1–>, –>3)-beta-D-Galp-(1–> and –>3)-alpha-D-Glcp-(1–> were distributed in the backbone or in the branch chains. The EPS-III had helix structure when dissolved in weak alkaline solution. It also had branched and intertwined form on the surface. The inhibition of alpha-glucosidase significantly increased as the increase of purity of exopolysaccharides.
2021
This review presents the main factors that influence the generation of biomass and metabolites by C. militaris. It outlines physiological and genetic factors that increase or reduce the manifestation of strain degeneration in C. militaris.
2021
The fruiting body of Cordyceps militaris (L.) Link, a well-known traditional medicinal mushroom, has been used in Korea for a long time to maintain health and longevity. The present study evaluated the inhibitory effects of the fruiting body of Cordyceps militaris on the growth of the non-small cell lung cancer cell line, NCI-H460
2021
Cordycepin (3′-deoxyadenosine) is a derivative of the nucleoside adenosine, differing from the latter by the absence of oxygen in the 3′ position of its ribose part. It was initially extracted from the rare parasitic fungus Cordyceps militaris and has now been synthesized.
2021
The mycelial biomass, antioxidant activity and production of extra- and intra-cellular polysaccharides production [EPS, IPS] of Cordyceps militaris strains AG-1, PSJ-1 were evaluated under different submerged liquid culture (SLC) conditions. At 24 0 C mycelial biomass and polysaccharide production of AG-1, PSJ-1 was optimal using PVC media and static culture conditions.
2020
The present study was conducted to investigate the anticancer properties of Cordyceps militaris grown on germinated soybeans (GSC) in human colon cancer HT-29 cells.
2020
Using fermented cordyceps powder Cs-4 as a substitute for natural cordyceps was benefit for life sciences. Therefore, it is of significance to investigate its main pharmacologically-active ingredients. In this work, fermented cordyceps polysaccharides with different molecular weights were isolated and purified. Various factors (i.e. extraction time, extraction power, and pH value) were investigated to obtain the response surface methodology values to most efficiently extract fermented cordyceps polysaccharides (FCP).
2019
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