About
Phellinus linteus, conocido como Mesima, es un hongo medicinal utilizado en la medicina tradicional asiática para tratar diversas enfermedades. Contiene polisacáridos y otros compuestos que exhiben efectos inmunomoduladores, anticancerígenos y antioxidantes. La Mesima causa una pudrición blanca en los morales y ha sido utilizada durante siglos en la medicina coreana y japonesa.
Flavors
Amargo
Phellinus linteus se describe a menudo como de sabor amargo, lo cual es una de las razones por las que no se utiliza típicamente en platos culinarios.
Textures
Difícil
El cuerpo fructífero de Mesima es duro y resistente.
Woody
Debido a su hábito de crecimiento y naturaleza, su textura es leñosa y no es adecuada para preparaciones culinarias típicas.
Fragrances
Terroso
Phellinus linteus tiene un aroma natural terroso.
Woody
Dado su crecimiento en raíces de árboles viejos, a veces puede tener un aroma ligeramente amaderado.
Physical Characteristics
Caps:
Con forma de pezuña, de hasta 15 cm de ancho. De color marrón amarillento a negro.
Gills:
Poros de color amarillo-marrón, 5-6 por mm.
Helps With
Cáncer
Demostrado para inducir apoptosis en células cancerosas e inhibir el crecimiento tumoral.
Inmunidad
Estimula la actividad de linfocitos y macrófagos
Inflamación
Exhibe efectos antiinflamatorios al inhibir TNF-alfa, IL-6 y óxido nítrico.
Medicinal Chemistry
Similar Species
Species: Phellinus ribis
Edibility: no comestible
Key Differences: Crece en una variedad de árboles, causa lesiones de chancro.
Species: Phellinus ribis
Edibility: no comestible
Mushroom Ratings
4.0
Based on 1 Review
5
★4
★3
★2
★1
★Share your thoughts
If you've consumed this mushroom, share your thoughts with our community
01/29/2025
Sam Matterson
References
Effects of hispolon on glioblastoma cell growth
Enhanced Mycelium Production of Phellinus igniarius (Agaricomycetes) Using a He-Ne Laser with Pulsed Light
Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways
Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus
Phellinus linteus grown on germinated brown rice increases cetuximab sensitivity of KRAS-mutated colon cancer
Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation
Modulation of T cell response by Phellinus linteus
Phellinus linteus grown on germinated brown rice suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-kB and Wnt/ß-catenin Signaling Pathways
A novel polysaccharide from mycelia of cultured Phellinus linteus displays antitumor activity through apoptosis
Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-kappaB activation
Hispolon is a polyphenolic compound isolated from <i>Phellinus linteus</i> which exhibits antitumor activity. Here, we explored the effects of hispolon on human glioblastoma cells U87MG. Cell viability was examined by MTT assay. Growth was investigated by incubating cells with various concentrations of hispolon (25 and 50 microM) for 24, 48 or 72 h and daily cell count. Cell cycle and apoptosis assay were assessed by flow cytometry. Hispolon decreased cell viability in a dose- and time-dependent manner.
2021
This study used a He-Ne laser with pulsed light irradiation to produce mutant strains of Phellinus igniarius strain JQ9 with enhanced characteristics for fermentation (17.685 ± 3.092 g/L) compared with the parent strain (12.062 ± 1.119 g/L). The combined treatment conditions were as follows: He-Ne laser irradiation for 30 min using a spot diameter of 10 mm, pulsed light treatment power set at 100 J, a treatment distance of 14.5 cm, and a flash frequency of 0.5 s. The production of bioactive polysaccharides and small biocompounds such as polyphenols, flavonoids, and triterpenes increased together with mycelium production.
2021
In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D(-)N (4(-)14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results.
2018
In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D(-)N (4(-)14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results.
2018
Colon cancer is one of the most common types of cancer, and it has recently become a leading cause of death worldwide. Among colon cancers, the v-ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated form is notorious for its non-druggable features. Cetuximab, a monoclonal antibody that binds to the epidermal growth factor receptor, has been introduced as an antitumor therapy; however, secondary resistance and side effects significantly limit its effective use in these cancers. In this study, we prepared Phellinus linteus on germinated brown rice (PBR) extracts to increase the sensitivity of KRAS-mutated colon cancers to cetuximab.
2017
The incidence of myocardial ischemia-reperfusion (IR) injury is rapidly increasing around the world and this disease is a major contributor to global morbidity and mortality. It is known that regulation of programmed cell death including apoptosis and autophagy reduces the impact of myocardial IR injury. In this study, the cardioprotective effects and underlying mechanisms of Phellinus linteus (Berk. and Curt.) Teng, Hymenochaetaceae (PL), a type of medicinal mushroom, were examined in rats subjected to myocardial IR injury. The left main coronary artery of rats was ligated for 1 h and reperfused for 3 h.
2017
Phellinus linteus, a species of mushroom, has been shown to contribute to health benefits, such as anti-inflammatory activity and immunomodulatory efficacy. The aim of this study was to analyze the most effective constituents of P. linteus fermented broths, polysaccharides, and to evaluate their immunoregulatory effects on T cells.
2016
Phellinus linteus is a mushroom with a variety of biological functions, such as antitumor and immunomodulating activities. P. linteus grown on germinated brown rice (PBR) feeding significantly decreased colon cancer metastasis to the lung and overall tumor size. In biomarker analysis, PBR showed significant anti-metastatic, anti-proliferative and pro-apoptotic activities. Detailed mechanistic studies highlighted that PBR strongly modulated MMP-2 and -9 activities and apoptotic biomarkers as well as decreased NF-κB, β-catenin, and mitogen-activated protein kinase (MAPK) expression. Together, these findings suggest that PBR is effective in preventing CRC by suppressing metastasis and proliferation and inducing apoptosis.
2015
Two novel polysaccharides termed PLPS-1 and PLPS-2 were isolated from mycelia of cultured Phellinus linteus by hot water extraction, purified by DEAE-52 cellulose and Sephadex G-100 column chromatography, and structurally characterized by FTIR and NMR spectroscopy, GC-MS, periodate oxidation/ Smith degradation, and methylation analysis. The monosaccharide compositions of PLPS-1 (MW 2.5×105 Da) and PLPS-2 (MW 2.8×104 Da) were respectively Glc, Ara, Fuc, Gal, and Xyl in molar ratio 21.964: 1.336: 1.182: 1: 1, and Glc, Gal, Man, Ara, Fuc, Xyl in molar ratio 14.368: 2.594: 1.956: 1.552: 1.466: 1; i.e., both were heteropolysaccharides.
2015
Hispidin, a polyphenol compound mainly derived from the valuable medicinal mushroom <i>Phellinus</i> species, has been found to possess distinct biological effects. However, the anti-inflammatory potential of hispidin still remains uncharacterized. RESULTS: In this study, the effects of hispidin on activation of nuclear factor kappa B (NF-kappaB) and the subsequent production of inducible nitric oxide synthase (iNOS) were determined in the lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cells. Our data indicated that hispidin inhibits transcriptional activity of NF-kappaB in a dose-dependent manner. Hispidin also attenuated LPS-induced NF-kappaB nuclear translocation and associated inhibitor of kappa B (IkappaB-alpha) degradation.
2015