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Phellinus Linteus

Phellinus Linteus

Common Names: Mesima, Sanghwang, Meshimakobu

Medicinal
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About

Phellinus linteus, known as Mesima, is a medicinal mushroom used in traditional Asian medicine to treat various illnesses. It contains polysaccharides and other compounds that exhibit immunomodulating, anticancer, and antioxidant effects. Mesima causes a white rot in mulberry trees and has been utilized for centuries in Korean and Japanese medicine.

Flavors

Bitter

Phellinus linteus is often described as having a bitter taste, which is one of the reasons it's not typically used in culinary dishes.

Textures

Hard

The fruiting body of Mesima is hard and tough.

Woody

Due to its growth habit and nature, its texture is woody and not suitable for typical culinary preparations.

Fragrances

Earthy

Phellinus linteus has a natural earthy aroma.

Woody

Given its growth on old tree roots, it can sometimes have a slightly woody scent.

Physical Characteristics

Caps:

Hoof-shaped, up to 15 cm wide. Yellow-brown to black.

Gills:

Yellow-brown pores, 5-6 per mm.

Helps With

Cancer

Shown to induce apoptosis in cancer cells and inhibit tumor growth

Immunity

Stimulates lymphocyte and macrophage activity

Inflammation

Exhibits anti-inflammatory effects by inhibiting TNF-alpha, IL-6, and nitric oxide

Medicinal Chemistry

Similar Species

Phellinus Ribis

Species: Phellinus ribis

Edibility: non-edible

Key Differences: Grows on variety of trees, causes canker lesions

Mushroom Ratings

4.0

Based on 1 Review

5

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3

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1

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Share your thoughts

If you've consumed this mushroom, share your thoughts with our community

Transformative Benefits of Phellinus linteus-Mesima for Mind and Body

01/29/2025

Sam Matterson

CalmContentFocusEnduranceEnergySpiritualDizzy
As an avid enthusiast of natural remedies, I recently discovered Phellinus linteus-Mesima mushrooms and they have truly transformed my wellness routine. After just a few weeks of incorporating these into my diet, I've experienced a remarkable increase in my focus and overall energy levels. The mushroom's unique properties appear to support cognitive function, which has been particularly beneficial for my chronic struggles with distraction. The calming effects have also enhanced my ability to manage stress, making me feel more centered and reflective throughout my day. I find that when I consume them in powdered form, whether in smoothies or as a tea infusion, they deliver the perfect balance of mental clarity and relaxation. While I am grateful for the benefits, I did want to note that I occasionally felt slight dizziness, so I ensure I stay hydrated. Overall, Phellinus linteus-Mesima has become an essential part of my lifestyle, particularly aiding my anxiety management and promoting better sleep patterns. I highly recommend this mushroom for anyone looking to enhance their mental and physical health naturally. Its versatility makes it an excellent addition for those exploring the power of fungi in their wellness journey.

References

  • Effects of hispolon on glioblastoma cell growth

    • Hispolon is a polyphenolic compound isolated from <i>Phellinus linteus</i> which exhibits antitumor activity. Here, we explored the effects of hispolon on human glioblastoma cells U87MG. Cell viability was examined by MTT assay. Growth was investigated by incubating cells with various concentrations of hispolon (25 and 50 microM) for 24, 48 or 72 h and daily cell count. Cell cycle and apoptosis assay were assessed by flow cytometry. Hispolon decreased cell viability in a dose- and time-dependent manner.

    2021

  • Enhanced Mycelium Production of Phellinus igniarius (Agaricomycetes) Using a He-Ne Laser with Pulsed Light

    • This study used a He-Ne laser with pulsed light irradiation to produce mutant strains of Phellinus igniarius strain JQ9 with enhanced characteristics for fermentation (17.685 ± 3.092 g/L) compared with the parent strain (12.062 ± 1.119 g/L). The combined treatment conditions were as follows: He-Ne laser irradiation for 30 min using a spot diameter of 10 mm, pulsed light treatment power set at 100 J, a treatment distance of 14.5 cm, and a flash frequency of 0.5 s. The production of bioactive polysaccharides and small biocompounds such as polyphenols, flavonoids, and triterpenes increased together with mycelium production.

    2021

  • Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways

    • In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D(-)N (4(-)14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results.

    2018

  • Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

    • In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D(-)N (4(-)14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results.

    2018

  • Phellinus linteus grown on germinated brown rice increases cetuximab sensitivity of KRAS-mutated colon cancer

    • Colon cancer is one of the most common types of cancer, and it has recently become a leading cause of death worldwide. Among colon cancers, the v-ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated form is notorious for its non-druggable features. Cetuximab, a monoclonal antibody that binds to the epidermal growth factor receptor, has been introduced as an antitumor therapy; however, secondary resistance and side effects significantly limit its effective use in these cancers. In this study, we prepared Phellinus linteus on germinated brown rice (PBR) extracts to increase the sensitivity of KRAS-mutated colon cancers to cetuximab.

    2017

  • Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation

    • The incidence of myocardial ischemia-reperfusion (IR) injury is rapidly increasing around the world and this disease is a major contributor to global morbidity and mortality. It is known that regulation of programmed cell death including apoptosis and autophagy reduces the impact of myocardial IR injury. In this study, the cardioprotective effects and underlying mechanisms of Phellinus linteus (Berk. and Curt.) Teng, Hymenochaetaceae (PL), a type of medicinal mushroom, were examined in rats subjected to myocardial IR injury. The left main coronary artery of rats was ligated for 1 h and reperfused for 3 h.

    2017

  • Modulation of T cell response by Phellinus linteus

    • Phellinus linteus, a species of mushroom, has been shown to contribute to health benefits, such as anti-inflammatory activity and immunomodulatory efficacy. The aim of this study was to analyze the most effective constituents of P. linteus fermented broths, polysaccharides, and to evaluate their immunoregulatory effects on T cells.

    2016

  • Phellinus linteus grown on germinated brown rice suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-kB and Wnt/ß-catenin Signaling Pathways

    • Phellinus linteus is a mushroom with a variety of biological functions, such as antitumor and immunomodulating activities. P. linteus grown on germinated brown rice (PBR) feeding significantly decreased colon cancer metastasis to the lung and overall tumor size. In biomarker analysis, PBR showed significant anti-metastatic, anti-proliferative and pro-apoptotic activities. Detailed mechanistic studies highlighted that PBR strongly modulated MMP-2 and -9 activities and apoptotic biomarkers as well as decreased NF-κB, β-catenin, and mitogen-activated protein kinase (MAPK) expression. Together, these findings suggest that PBR is effective in preventing CRC by suppressing metastasis and proliferation and inducing apoptosis.

    2015

  • A novel polysaccharide from mycelia of cultured Phellinus linteus displays antitumor activity through apoptosis

    • Two novel polysaccharides termed PLPS-1 and PLPS-2 were isolated from mycelia of cultured Phellinus linteus by hot water extraction, purified by DEAE-52 cellulose and Sephadex G-100 column chromatography, and structurally characterized by FTIR and NMR spectroscopy, GC-MS, periodate oxidation/ Smith degradation, and methylation analysis. The monosaccharide compositions of PLPS-1 (MW 2.5×105 Da) and PLPS-2 (MW 2.8×104 Da) were respectively Glc, Ara, Fuc, Gal, and Xyl in molar ratio 21.964: 1.336: 1.182: 1: 1, and Glc, Gal, Man, Ara, Fuc, Xyl in molar ratio 14.368: 2.594: 1.956: 1.552: 1.466: 1; i.e., both were heteropolysaccharides.

    2015

  • Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-kappaB activation

    • Hispidin, a polyphenol compound mainly derived from the valuable medicinal mushroom <i>Phellinus</i> species, has been found to possess distinct biological effects. However, the anti-inflammatory potential of hispidin still remains uncharacterized. RESULTS: In this study, the effects of hispidin on activation of nuclear factor kappa B (NF-kappaB) and the subsequent production of inducible nitric oxide synthase (iNOS) were determined in the lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cells. Our data indicated that hispidin inhibits transcriptional activity of NF-kappaB in a dose-dependent manner. Hispidin also attenuated LPS-induced NF-kappaB nuclear translocation and associated inhibitor of kappa B (IkappaB-alpha) degradation.

    2015
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